Enoxolone EP (ANSM-ASMF No.-2013-079)

Alchem International with 75 years of experience in the phytochemical space has been diligently providing plant derived ingredients, active pharmaceutical ingredients and bulk drugs to all international significant geographies.


The success of the company’s operations lie in its proprietary manufacturing processes, intensive research, willingness to combat new challenges, mesh with evolving technologies ,focussed expansion and credible response  to international validations and inspections.

The production sites are US FDA approved and WHO and EU GMP certified. The company has filed ASMF/DMFs in over 20 countries worldwide. Value additions through bio-technology, semi-synthesis and foot prints in the formulation space have happened in planned progression. Alchem’s interest in skin care is a logical part of this dimensional growth.

Sheer Quality drives Alchem’s operations

Through perfect blend of science and nature, dedicated research, selection of finest botanical herbal extracts and focused technology, Alchem has successfully extracted the potent active molecules in the plant and offers it for pharmaceutical use to help various companies spread wellness.

Enoxolone
"For pharmaceutical use, Alchem offers Enoxolone with all its inherent benefits"

Glycyrrhiza glabra, also known as licorice and sweetwood, is native to the Mediterranean and certain areas of Asia. The primary antioxidant and anti-inflammatory compounds found in Licorice Root are the glycosides - glycyrrhizin and glycyrrizinic acid, flavonoids, and saponins. Glycyrrhizin, a triterpenoid compound, accounts for the sweet taste of licorice root. This compound represents a mixture of potassium-calcium-magnesium salts of glycyrrhizic acid that varies within a 2-25 percent range. Enoxolone is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid. It has antioxidant, expectorant, antitussive, antiulcer, anti-inflammatory, antiallergic, anti- antibacterial, antiviral, antifungal and antiprotozoal properties.

Enoxolone inhibits 15-hydroxyprostaglandin dehydrogenase and Δ13-prostaglandin reductase. Inhibition of these two enzymes stimulates an increase in the concentration of prostaglandins E and F2α in the stomach, which promotes the healing of peptic ulcers owing to a cytoprotective effect on the gastric mucosa. It involves acceleration of mucin excretion through increasing the synthesis of glycoprotein at the gastric mucosa, prolonging the life of the epithelial cells, and antipepsin activity.

Enoxolone is used for sweetening, flavoring and pharmaceutical applications. It is used in brewing and for confectionery and tobacco flavorings. It is frequently used in medicines to mask the bitter taste of drugs like aloe and quinine. It is also used to relieve oral inflammations, irritable condition of bronchial tubes, hoarseness, dry coughs, bronchitis, asthma, sore throats and in viral infections. It is used in healing of peptic ulcer and warm sensation on mucus membrane. It has spasmolytic antiulcer properties, and useful in gastralgia, gastric ulcer, hypo and hyper acidity, and peptic ulcer.

The product addresses broad spectrum physiological concerns and has the band width and capabilities to meet expectations. Regular use should exhibit demonstrable results to inhibit various health related issues.